Associate Professor Barbara Rolfe
Associate Professor & Principal Research Fellow and Group Leader
Australian Institute for Bioengineering and Nanotechnology
+61 7 33463856
+61 7 334 63856
Academic Background
BSc, PhD UQ
Research: The Innate Immune System, Cancer Therapeutics and Biomedical Applications of Nanomaterials.
Dr Barbara Rolfe is an immunologist and cell biologist is an immunologist and cell biologist whose research focuses on myeloid cells and the innate immune response. Her research investigates key questions in biomedical research: 1) biomedical applications of nanomaterials, and how the immune response to nanoparticles influences their in vivo fate, and 2) the application of complement-targeting drugs as cancer therapeutics.
Researcher biography
A/Prof Barbara Rolfe is a Group Leader at the Australian Institute for Bioengineering and Nanotechnology. A/Prof Rolfe is an immunologist and cell biologist, whose major research interests are the role of the innate immune system in cancer, the identification of novel therapeutic strategies for cancer, and nanomaterial safety. Her research has led to the identification of a previously unknown mechanism by which dysregulation of the immune system contributes to cancer development and growth, and provided information regarding the immune response to nanomaterials and the influence of physicochemical characteristics on biodistribution and cellular uptake. A/Prof Rolfe has used mouse models and small peptide agonists and antagonists to investigate the role of the innate immune system in tumour development and growth. This research demonstrated for the first time an important role for complement proteins in promoting tumour growth via regulation of immunosuppressive innate immune cells. Ongoing research is aimed focussed on gaining a better understanding of the role of complement proteins in tumour growth, developing novel immunotherapeutic strategies for cancer and investigating the application of nanomaterials for targeted delivery of anti-cancer drugs.
Book Chapters
Sonderegger, Stefan E., Manzanero, Silvia, Woodruff, Trent M., Farouqa, Jad, Nabizadeh, Jamileh, Panagides, Nadya and Rolfe, Barbara E. (2024). The role of the complement system in cancer etiology and management. Clinical immuno-oncology. (pp. 41-60.e10) edited by John E. Niederhuber. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-87763-3.00012-5
Gu, Z., Rolfe, Barbara E., Thomas, A. C., Campbell, Julie H., Lu, G. Q. Max and Xu, Z. P. (2012). Heparin-related nanomaterials. Heparin, properties, uses and side effects. (pp. 159-178) edited by David E. Piyathilake and Rhong Liang. New York, United States: Nova Science.
Rolfe, Barbara, Mooney, Jane, Zhang, Bing, Jahnke, Sani, Le, Sarah-Jane, Chau, Yu-Qian, Huang, Qiping, Wang, Hao, Campbell, Gordon and Campbell, Julie (2011). The fibrotic response to implanted biomaterials: Implications for tissue engineering. Regenerative Medicine and Tissue Engineering: Cells and Biomaterials. (pp. 551-568) edited by Daniel Eberli. Rijeka, Croatia: InTech Publishing.
Journal Articles
Ortiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos ... Pio, Ruben (2022). Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Letters, 529, 70-84. doi: 10.1016/j.canlet.2021.12.027
Gorman, Declan M., Li, Xaria X., Lee, John D., Fung, Jenny N., Cui, Cedric S., Lee, Han Siean, Rolfe, Barbara E., Woodruff, Trent M. and Clark, Richard J. (2021). Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. Journal of Medicinal Chemistry, 64 (22) acs.jmedchem.1c01174, 16598-16608. doi: 10.1021/acs.jmedchem.1c01174
Akhir, Fazrena Nadia Md, Noor, Mohd Hezmee Mohd, Leong, Keith Weng Kit, Nabizadeh, Jamileh A., Manthey, Helga D., Sonderegger, Stefan E., Fung, Jenny Nga Ting, McGirr, Crystal E., Shiels, Ian A., Mills, Paul C., Woodruff, Trent M. and Rolfe, Barbara E. (2021). An immunoregulatory role for complement receptors in murine models of breast cancer. Antibodies, 10 (1) 2, 1-12. doi: 10.3390/antib10010002
Zhang, Cheng, Moonshi, Shehzahdi Shebbrin, Wang, Wenqian, Ta, Hang Thu, Han, Yanxiao, Han, Felicity Y., Peng, Hui, Král, Petr, Rolfe, Barbara E., Gooding, J. Justin, Gaus, Katharina and Whittaker, Andrew K. (2020). Correction to High F-content perfluoropolyether-based nanoparticles for targeted detection of breast cancer by 19F magnetic resonance and optical imaging. ACS Nano, 14 (10), 14245-14246. doi: 10.1021/acsnano.0c07373
Rolfe, Barbara E., Pio, Ruben, Woodruff, Trent M., Markiewski, Maciej M. and Manthey, Helga D. (2020). Editorial: The Role of Complement in Tumors. Frontiers in Immunology, 11 139, 139. doi: 10.3389/fimmu.2020.00139
Nabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., Akhir, Fazrena N. M., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. FASEB Journal, 33 (10), fj201800980RR-11071. doi: 10.1096/fj.201800980rr
Chen, Weiyu, Zuo, Huali, Rolfe, Barbara, Schembri, Mark A., Cobbold, Rowland N., Zhang, Bing, Mahony, Timothy J. and Xu, Zhi Ping (2018). Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli. Journal of Controlled Release, 292, 196-209. doi: 10.1016/j.jconrel.2018.11.008
Yan, Shiyu, Xu, Kewei, Li, Li, Gu, Wenyi, Rolfe, Barbara E. and Xu, Zhi P. (2018). The pathways for layered double hydroxide nanoparticles to enhance antigen (cross)-presentation on immune cells as adjuvants for protein vaccines. Frontiers in Pharmacology, 9 (SEP) 1060, 1060. doi: 10.3389/fphar.2018.01060
Chen, Liyu, Glass, Joshua J., De Rose, Robert, Sperling, Claudia, Kent, Stephen J., Houston, Zachary H., Fletcher, Nicholas L., Rolfe, Barbara E. and Thurecht, Kristofer J. (2018). Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles. ACS Applied Bio Materials, 1 (3) acsabm.8b00220, 756-767. doi: 10.1021/acsabm.8b00220
Zhang, Cheng, Moonshi, Shehzahdi Shebbrin, Wang, Wenqian, Ta, Hang Thu, Han, Yanxiao, Han, Felicity Y., Peng, Hui, Král, Petr, Rolfe, Barbara E., Gooding, John Justin, Gaus, Katharina and Whittaker, Andrew Keith (2018). High F-content perfluoropolyether-based nanoparticles for targeted detection of breast cancer by 19F magnetic resonance and optical imaging. ACS Nano, 12 (9) acsnano.8b03726, 9162-9176. doi: 10.1021/acsnano.8b03726
Chen, Weiyu, Zuo, Huali, Li, Bei, Duan, Chengcheng, Rolfe, Barbara, Zhang, Bing, Mahony, Timothy J and Xu, Zhi Ping (2018). Clay nanoparticles elicit long-term immune responses by forming biodegradable depots for sustained antigen stimulation. Small, 14 (19) 1704465, e1704465. doi: 10.1002/smll.201704465
Fanning, Jonathon P., See Hoe, Louise E., Passmore, Margaret R., Barnett, Adrian G., Rolfe, Barbara E., Millar, Jonathan E., Wesley, Allan J., Suen, Jacky and Fraser, John F. (2018). Differential immunological profiles herald magnetic resonance imaging-defined perioperative cerebral infarction. Therapeutic Advances in Neurological Disorders, 11, 1756286418759493. doi: 10.1177/1756286418759493
Yan, Shiyu, Gu, Wenyi, Zhang, Bing, Rolfe, Barbara E and Xu, Zhi Ping (2017). High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations. Dalton Transactions, 47 (9), 2956-2964. doi: 10.1039/c7dt03725b
Chen, Liyu, Simpson, Joshua D, Fuchs, Adrian V, Rolfe, Barbara E and Thurecht, Kristofer J (2017). Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice. Molecular pharmaceutics, 14 (12), 4485-4497. doi: 10.1021/acs.molpharmaceut.7b00611
Gu, Zi, Yan, Shiyu, Cheong, Soshan, Cao, Zhenbang, Zuo, Huali, Thomas, Anita C., Rolfe, Barbara E. and Xu, Zhi Ping (2017). Layered double hydroxide nanoparticles: Impact on vascular cells, blood cells and the complement system. Journal of Colloid and Interface Science, 512, 404-410. doi: 10.1016/j.jcis.2017.10.069
Chen, Weiyu, Zuo, Huali, Mahony, Timothy J, Zhang, Bing, Rolfe, Barbara and Xu, Zhi Ping (2017). Efficient induction of comprehensive immune responses to control pathogenic E. coli by clay nano-adjuvant with the moderate size and surface charge. Scientific reports, 7 (1) 13367, 1-12. doi: 10.1038/s41598-017-13570-2
Nabizadeh, Jamileh A., Manthey, Helga D., Steyn, Frederik J., Chen, Weiyu, Widiapradja, Alexander, Akhir, Fazrena N. Md, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2016). The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. Journal of Immunology, 196 (11), 4783-4792. doi: 10.4049/jimmunol.1600210
Chen, Weiyu, Zhang, Bing, Mahony, Timothy, Gu, Wenyi, Rolfe, Barbara and Xu, Zhi Ping (2016). Efficient and durable vaccine against Intimin β of Diarrheagenic E. Coli induced by clay nanoparticles. Small, 12 (12), 1627-1639. doi: 10.1002/smll.201503359
Ma, Yiming, Fuchs, Adrian V., Boase, Nathan R. B., Rolfe, Barbara E., Coombes, Allan G. A. and Thurecht, Kristofer J. (2015). The in vivo fate of nanoparticles and nanoparticle-loaded microcapsules after oral administration in mice: evaluation of their potential for colon-specific delivery. European Journal of Pharmaceutics and Biopharmaceutics, 94, 393-403. doi: 10.1016/j.ejpb.2015.06.014
Yan, Shiyu, Rolfe, Barbara E., Zhang, Bing, Mohammed, Yousuf H., Gu, Wenyi and Xu, Zhi P. (2014). Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG. Biomaterials, 35 (35), 9508-9516. doi: 10.1016/j.biomaterials.2014.07.055
Pearce, Amanda K., Rolfe, Barbara E., Russell, Pamela J., Tse, Brian W.-C., Whittaker, Andrew K., Fuchs, Adrian V. and Thurecht, Kristofer J. (2014). Development of a polymer theranostic for prostate cancer. Polymer Chemistry, 5 (24), 6932-6942. doi: 10.1039/C4PY00999A
Boase, Nathan R. B., Blakey, Idriss, Rolfe, Barbara E., Mardon, Karine and Thurecht, Kristofer J. (2014). Synthesis of a multimodal molecular imaging probe based on a hyperbranched polymer architecture. Polymer Chemistry, 5 (15), 4450-4458. doi: 10.1039/c4py00513a
Mooney, Jane E., Summers, Kim M., Gongora, Milena, Grimmond, Sean M., Campbell, Julie H., Hume, David A. and Rolfe, Barbara E. (2014). Transcriptional switching in macrophages associated with the peritoneal foreign body response. Immunology and Cell Biology, 92 (6), 518-526. doi: 10.1038/icb.2014.19
Rolfe, Barbara E., Blakey, Idriss, Squires, Oliver, Peng, Hui, Boase, Nathan R. B., Alexander, Cameron, Parsons, Peter G., Boyle, Glen M., Whittaker, Andrew K. and Thurecht, Kristofer J. (2014). Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. Journal of the American Chemical Society, 136 (6), 2413-2419. doi: 10.1021/ja410351h
Gu, Zi, Rolfe, Barbara E., Thomas, Anita C. and Xu, Zhi Ping (2013). Restenosis treatments using nanoparticle-based drug delivery systems. Current Pharmaceutical Design, 19 (35), 6330-6339. doi: 10.2174/1381612811319350009
Abidin, Nor Ishida Zainal, Rolfe, Barbara, Owen, Helen, Malisano, Julian, Martin, Darren, Hofstetter, Joelle, Uggowitzer, Peter J. and Atrens, Andrej (2013). The in vivo and in vitro corrosion of high-purity magnesium and magnesium alloys WZ21 and AZ91. Corrosion Science, 75, 354-366. doi: 10.1016/j.corsci.2013.06.019
Matsumoto, Aya, Manthey, Helga D., Marsh, Susan A., Fassett, Robert G., de Haan, Judy B., Rolfe, Barbara E. and Coombes, Jeff S. (2013). Effects of exercise training and RhoA/ROCK inhibition on plaque in ApoE−/− mice. International Journal of Cardiology, 167 (4), 1282-1288. doi: 10.1016/j.ijcard.2012.03.172
Coles, Daniel J., Rolfe, Barbara E., Boase, Nathan R. B., Veedu, Rakesh N. and Thurecht, Kristofer J. (2013). Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo. Chemical Communications, 49 (37), 3836-3838. doi: 10.1039/c3cc00127j
Gu, Zi, Rolfe, Barbara E., Xu, Zhi Ping, Campbell, Julie H., Lu, G. Q. (Max) and Thomas, Anita C. (2012). Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles. Advanced Healthcare Materials, 1 (5), 669-673. doi: 10.1002/adhm.201200069
Hezmee, M. N. M., Shiels, I. A., Rolfe, B. E. and Mills, P. C. (2012). Complement C5a: Impact on the field of veterinary medicine. The Veterinary Journal, 192 (3), 264-271. doi: 10.1016/j.tvjl.2011.12.008
Gu, Zi, Rolfe, Barbara E., Thomas, Anita C., Campbell, Julie H., Lu, G.Q. (Max) and Xu, Zhi P. (2011). Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells. Biomaterials, 32 (29), 7234-7240. doi: 10.1016/j.biomaterials.2011.05.083
Chau, Lien T., Rolfe, Barbara E. and Cooper-White, Justin J. (2011). A microdevice for the creation of patent, three-dimensional endothelial cell-based microcirculatory networks. Biomicrofluidics, 5 (3) 034115, Article number 034115-3411514. doi: 10.1063/1.3609264
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011). Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 (7), 2447-2455. doi: 10.1096/fj.10-174284
Zhu, Congli, Zhang, Liang, Zheng, Yong, Xu, Jing, Song, Jian, Rolfe, Barbara E. and Campbell, Julie H. (2011). Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: A novel mechanism for the "time window theory" of menopausal hormone therapy. Atherosclerosis, 215 (2), 294-300. doi: 10.1016/j.atherosclerosis.2010.12.025
Hezmee, Mohd Noor Mohd, Kyaw-Tanner, Myat, Lee, Jia Yu Peppermint, Shiels, Ian A., Rolfe, Barbara, Woodruff, Trent and Mills, Paul C. (2011). Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors. Veterinary Immunology and Immunopathology, 139 (1), 50-56. doi: 10.1016/j.vetimm.2010.08.005
Gu, Zi, Rolfe, Barbara E., Xu, Zhi P., Thomas, Anita C., Campbell, Julie H. and Lu, Gao Q.M. (2010). Enhanced effects of low molecular weight heparin intercalated with layered double hydroxide nanoparticles on rat vascular smooth muscle cells. Biomaterials, 31 (20), 5455-5462. doi: 10.1016/j.biomaterials.2010.03.050
Le, S. J., Gongora, M., Zhang, B., Grimmond, S., Campbell, G. R., Campbell, J. H. and Rolfe, B. E. (2010). Gene expression profile of the fibrotic response in the peritoneal cavity. Differentiation, 79 (4-5), 232-243. doi: 10.1016/j.diff.2010.03.001
Mooney, Jane E., Rolfe, Barbara E., Osborne, Geoffrey W., Sester, David P., van Rooijen, Nico, Campbell, Gordon R., Hume, David A. and Campbell, Julie H. (2010). Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. American Journal of Pathology, 176 (1), 369-380. doi: 10.2353/ajpath.2010.090545
Cao, Yang, Zhang, Bing, Croll, Tristan, Rolfe, Barbara E., Campbell, Julie H., Campbell, Gordon R., Martin, Darren and Cooper-White, Justin J. (2008). Engineering tissue tubes using novel multilayered scaffolds in the rat peritoneal cavity. Journal of Biomedical Materials Research. Part A, 87A (3), 719-727. doi: 10.1002/jbm.a.31781
Campbell, Gordon R., Geoffrey Turnbull, Xiang, Lina, Haines, Michael, Shannon Armstrong, Rolfe, Barbara E. and Campbell, Julie H. (2008). The peritoneal cavity as a bioreactor for tissue engineering visceral organs: bladder, uterus and vas deferens. Journal of Tissue Engineering and Regenerative Medicine, 2 (1), 50-60. doi: 10.1002/term.66
Knoner, Gregor, Rolfe, Barbara E., Campbell, Julie H., Parkin, Simon J., Heckenberg, Norman R. and Rubinsztein-Dunlop, Halina (2006). Mechanics of cellular adhesion to artificial artery templates. Biophysical Journal, 91 (8), 3085-3096. doi: 10.1529/biophysj.105.076125
Levick, Scott, Loch, David, Rolfe, Barbara, Reid, Robert C., Fairlie, David P., Taylor, Stephan M. and Brown, Lindsay (2006). Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive rats. Journal of Immunology, 176 (11), 7000-7007. doi: 10.4049/jimmunol.176.11.7000
Cao, Yang, Zhang, Bing, Croll, Tristan I., Rolfe, Barbara E., Campbell, Julie H., Campbell, Gordon R., Martin, Darren J. and Cooper-White, Justin J. (2006). Engineering tissue tubes using novel multilayered scaffolds in the rabbit and rat peritoneal cavity. Tissue Engineering, 12 (4), 1020-1021.
Hoenig, Michel R., Rolfe, Barbara E. and Campbell, Julie H. (2006). Cholestanol: A serum marker to guide LDL cholesterol-lowering therapy. Atherosclerosis, 184 (2), 247-254. doi: 10.1016/j.atherosclerosis.2005.09.007
Mooney, J. E., Rolfe, B. E., Zhang, B., Sester, P., Campbell, J. H. and Campbell, G. R. (2006). Monocytes/macrophages and foreign body encapsulation in the peritoneal cavity. Cytometry Part A, 69A (5), 421-421.
Le, S., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (2006). Life and death in developing myofibroblast capsules. Cytometry Part A, 69A (5), 419-419. doi: 10.1002/cyto.a.20264
Rolfe, B. E., Zhang, B., Wigan, M. P., Pearson, K., Chen, Y., Pantarat, S., Campbell, J. H., Jahnke, S, Chau, Y. and Campbell, G. R. (2006). Growth factor regulation of myofibroblast differentiation. Cytometry Part A, 69A (5), 423-424.
Hoenig, Michel R., Campbell, Gordon R., Rolfe, Barbara E. and Campbell, Julie H. (2005). Tissue-engineered blood vessels: Alternative to autologous grafts?. Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (6), 1128-1134. doi: 10.1161/01.ATV.0000158996.03867.72
Rolfe, B. E., Worth, N. F., World, C. J., Campbell, J. H. and Campbell, G. R. (2005). Rho and vascular disease. Atherosclerosis, 183 (1), 1-16. doi: 10.1016/j.atherosclerosis.2005.04.023
Worth, N. F., Campbell, G. R., Campbell, J. H. and Rolfe, B. E. (2004). Rho expression and activation in vascular smooth muscle cells. Cell Motility and the Cytoskeleton, 59 (3), 189-200. doi: 10.1002/cm.20036
World, Cameron, Rolfe, Barbara and Campbell, Julie (2004). THE THERAPEUTIC ACTIONS OF LIF ON THE VASCULATURE. Cardiovascular Pathology, 13 (3), 61. doi: 10.1016/j.carpath.2004.03.179
World, C.J., Merrilees, M.J., Beaumont, B., Campbell, G. R., Campbell, J. H. and Rolfe, B. E. (2004). The effects of leukemia inhibitory factor (LIF) on neointimal formation in injured arteries. Biomedical Research, 15 (2), 169-175.
Rolfe, Barbara E., Stamatiou, Steve, World, Cameron J., Brown, Lindsay, Thomas, Anita C., Bingley, John A., Worth, Nathalie F. and Campbell, Julie H. (2003). Leukaemia inhibitory factor retards the progression of atherosclerosis. Cardiovascular Research, 58 (1), 222-230. doi: 10.1016/S0008-6363(02)00832-5
Worth, N. F., Rolfe, B. E., Campbell, J. H. and Campbell, G. R. (2003). Rho and smooth muscle cell phenotype. International Congress Series, 1262 (C), 111-114. doi: 10.1016/S0531-5131(03)01863-6
Worth, N. F., Rolfe, B. E., Song, J. and Campbell, G. R. (2001). Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins. Cell Motility And The Cytoskeleton, 49 (3), 130-145. doi: 10.1002/cm.1027
Song, J., Rolfe, B. E., Hayward, I. P., Campbell, G. R. and Campbell, J. H. (2001). Reorganization of structural proteins in vascular smooth muscle cells grown in collagen gel and basement membrane matrices (Matrigel): A comparison with their in situ counterparts. Journal of Structural Biology, 133 (1), 43-54. doi: 10.1006/jsbi.2001.4327
World, C., Rolfe, B. E. and Campbell, J. H. (2001). Regulation of LIF receptor expression in vascular smooth muscle. Annals of the New York Academy of Sciences, 947 (1), 323-328. doi: 10.1111/j.1749-6632.2001.tb03956.x
Rolfe, B. E., Muddiman, J. D., Smith, N. J., Campbell, G. R. and Campbell, J. H. (2000). ICAM-1expression by vascular smooth muscle cells is phenotype-dependent. Atherosclerosis, 149 (1), 99-110. doi: 10.1016/S0021-9150(99)00322-6
Song, J., Worth, N. F., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (2000). Heterogeneous distribution of isoactins in cultured vascular smooth muscle cells does not reflect segregation of contractile and cytoskeletal domains. Journal of Histochemistry & Cytochemistry, 48 (11), 1441-1452. doi: 10.1177/002215540004801101
Thomas, A. C., Campbell, J. H., Rolfe, B. E. and Campbell, G. R. (2000). Do sub-populations of smooth muscle cells exist in the artery wall?. Journal of Molecular and Cellular Cardiology, 30, A40-A40.
Badorrek, B., Rolfe, B. E., Campbell, J. H. and Campbell, G. R. (2000). Cuff-induced intimal thickening in the carotid artery of the marmoset. Biomedical Research, 11 (2), 179-188.
Song, J., Rolfe, B. E., Hayward, I. P., Campbell, G. R. and Campbell, J. H. (2000). Effects of collagen gel configuration on behavior of vascular smooth muscle cells in vitro: association with vascular morphogenesis. In Vitro Cellular and Developmental Biology, 36 (9), 600-610. doi: 10.1290/1071-2690(2000)036
Uzal, FA, Rolfe, BE, Smith, NJ, Thomas, AC and Kelly, WR (1999). Resistance of Ovine, Caprine and Bovine Endothelial Cells to Clostridium perfringens type D Epsilon Toxin In Vitro. Veterinary Research Communications, 23 (5), 275-284. doi: 10.1023/A:1006362819202
Song, J., Wan, Y., Rolfe, B. E., Campbell, J. H. and Campbell, G. R. (1998). Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype. Atherosclerosis, 140 (1), 97-104. doi: 10.1016/S0021-9150(98)00122-1
Song, J., Rolfe, B. E., Campbell, J. H. and Campbell, G. R. (1998). Changes in three-dimensional architecture of microfilaments in cultured vascular smooth muscle cells during phenotypic modulation. Tissue & Cell, 30 (3), 324-333. doi: 10.1016/S0040-8166(98)80045-1
Rolfe, B.E., Campbell, J.H., Smith, N.J., Cheong, M.W. and Campbell, G.R. (1995). T-Lymphocytes Affect Smooth-Muscle Cell Phenotype and Proliferation. Arteriosclerosis Thrombosis and Vascular Biology, 15 (8), 1204-1210. doi: 10.1161/01.ATV.15.8.1204
Rolfe, BE, Athanasasplatsis, S, Hoskin, MJ, Morton, H and Cavanagh, AC (1995). Purification and Partial Characterization of An Early-Pregnancy Factor-Induced Suppressor Factor (epf-S-1). American Journal of Reproductive Immunology, 33 (6), 485-494. doi: 10.1111/j.1600-0897.1995.tb00911.x
Athanasasplatsis, S, Hoskin, MJ, Rolfe, BE, Cavanagh, AC and Morton, H (1995). A Monoclonal-Antibody to An Early-Pregnancy Factor-Induced Suppressor Factor (epf-S-1) Disrupts Implantation in Mice. American Journal of Reproductive Immunology, 33 (3), 259-266. doi: 10.1111/j.1600-0897.1995.tb00893.x
Morton, H., Rolfe, B. E. and Cavanagh, A. C. (1992). Early-Pregnancy Factor. Seminars in Reproductive Endocrinology, 10 (2), 72-82. doi: 10.1055/s-2007-1018863
Morton, H, Cavanagh, AC, Athanasasplatsis, S, Quinn, KA and Rolfe, BE (1992). Early-Pregnancy Factor Has Immunosuppressive and Growth-Factor Properties. Reproduction Fertility and Development, 4 (4), 411-422. doi: 10.1071/RD9920411
Cavanagh, AC, Rolfe, BE, Athanasasplatsis, S, Quinn, KA and Morton, H (1991). Relationship Between Early-Pregnancy Factor, Mouse Embryo-Conditioned Medium and Platelet-Activating-Factor. Journal of Reproduction and Fertility, 93 (2), 355-365. doi: 10.1530/jrf.0.0930355
Cavanagh, AC, Morton, H, Athanasasplatsis, S, Quinn, KA and Rolfe, BE (1991). Identification of a Putative Inhibitor of Early-Pregnancy Factor in Mice. Journal of Reproduction and Fertility, 91 (1), 239-248. doi: 10.1530/jrf.0.0910239
Quinn, KA, Athanasasplatsis, S, Wong, TY, Rolfe, BE, Cavanagh, AC and Morton, H (1990). Monoclonal-Antibodies to Early-Pregnancy Factor Perturb Tumor-Cell Growth. Clinical and Experimental Immunology, 80 (1), 100-108. doi: 10.1111/j.1365-2249.1990.tb06448.x
Athanasasplatsis, S, Quinn, KA, Wong, TY, Rolfe, BE, Cavanagh, AC and Morton, H (1989). Passive-Immunization of Pregnant Mice Against Early-Pregnancy Factor Causes Loss of Embryonic Viability. Journal of Reproduction and Fertility, 87 (2), 495-502. doi: 10.1530/jrf.0.0870495
Rolfe B., Quinn K., Athanasas S., Cavanagh A. and Morton H. (1989). Genetically-restricted effector molecules released by human lymphocytes in response to early pregnancy factor.. Immunology and cell biology, 67 (3), 205-208. doi: 10.1038/icb.1989.31
Rolfe, BE, Cavanagh, AC, Quinn, KA and Morton, H (1988). Identification of 2 Suppressor Factors Induced by Early-Pregnancy Factor. Clinical and Experimental Immunology, 73 (2), 219-225.
Morton, H, Rolfe, BE and Cavanagh, AC (1987). Ovum Factor and Early-Pregnancy Factor. Current Topics in Developmental Biology, 23, 73-92.
Morton, Halle, Rolfe, Barbara E. and Cavanagh, Alice C. (1987). OVUM factor and early pregnancy factor. Current Topics in Developmental Biology, 23 (C), 73-92. doi: 10.1016/S0070-2153(08)60620-1
Rolfe, Barbara, Cavanagh, Alice, Forde, Caron, Bastin, Fern, Chen, Christopher and Morton, Halle (1984). Modified rosette inhibition test with mouse lymphocytes for detection of early pregnancy factor in human pregnancy serum. Journal of Immunological Methods, 70 (1), 1-11. doi: 10.1016/0022-1759(84)90383-1
Rolfe, BE, Morton, H, Cavanagh, AC and Gardiner, RA (1983). Detection of An Early-Pregnancy Factor-Like Substance in Sera of Patients with Testicular Germ-Cell Tumors. American Journal of Reproductive Immunology, 3 (2), 97-100. doi: 10.1111/j.1600-0897.1983.tb00223.x
Rolfe, BE, Morton, H and Clarke, FM (1983). Early-Pregnancy Factor Is An Immunosuppressive Contaminant of Commercial Preparations of Human Chorionic-Gonadotropin. Clinical and Experimental Immunology, 51 (1), 45-52.
Rolfe, BE (1982). Detection of Fetal Wastage. Fertility and Sterility, 37 (5), 655-660. doi: 10.1016/S0015-0282(16)46278-3
Cavanagh, AC, Morton, H, Rolfe, BE and Gidleybaird, AA (1982). Ovum Factor - a 1st Signal of Pregnancy. American Journal of Reproductive Immunology, 2 (2), 97-101. doi: 10.1111/j.1600-0897.1982.tb00093.x
Morton, Halle, Tinneberg, Hans-Rudolf, Rolfe, Barbara, Wolf, Marianne and Mettler, Lilo (1982). Rosette inhibition test: A multicentre investigation of early pregnancy factor in humans. Journal of Reproductive Immunology, 4 (5), 251-261. doi: 10.1016/0165-0378(82)90001-8
Morton, H., Rolfe, B. E., McNeill, L., Clarke, P., Clarke, F. M. and Clunie, G. J. A. (1980). Early pregnancy factor: tissues involved in its production in the mouse. Journal of Reproductive Immunology, 2 (2), 73-82. doi: 10.1016/0165-0378(80)90044-3
Clarke, FM, Morton, H, Rolfe, BE and Clunie, Gja (1980). Partial Characterization of Early-Pregnancy Factor in the Sheep. Journal of Reproductive Immunology, 2 (3), 151-162. doi: 10.1016/0165-0378(80)90033-9
Morton, Halle, Rolfe, Barbara, Clunie, Gordon J. A, Anderson, Margaret J. and Morrison, John (1977). An early pregnancy factor detected in human serum by the Rosette Inhibition Test. The Lancet, 309 (8008), 394-397. doi: 10.1016/S0140-6736(77)92605-8
MORTON, H, ROLFE, B, CLUNIE, GJA, ANDERSON, MJ and MORRISON, J (1977). EARLY-PREGNANCY FACTOR DETECTED IN HUMAN-SERUM BY ROSETTE INHIBITION TEST. Lancet, 1 (8008), 394-397.
Conference Papers
Rolfe, Barbara, Sonderegger, Stefan, McGirr, Crystal and Woodruff, Trent (2022). Immunoregulatory role for complement receptors in murine breast cancer. 28th Virtual International Complement Workshop (ICW) of the International-Complement-Society (ICS), Virtual, 6-10 December 2021. Oxford, United Kingdom: Elsevier.
Nabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany: Wiley.
Zhang, Cheng, Moonshi, Shehzahdi Shebbrin, Ta, Hang T., Han, Yanxiao, Han, Felicity Y., Peng, Hui, Král, Petr, Rolfe, Barbara E. and Whittaker, Andrew K. (2018). High F-Content Perfluoropolyether-based Polymers for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging. World Polymer Congress Macro 2018, Cairns QLD Australia, 1-5 July 2018.
Varanasi, S., Wang, D., Peng, H., Do, H.L., Smid, J., Rolfe, B., Rasoul, F., Whittaker, A.K. and Symons, A. (2010). Effect of hydrogels or lipoxinA4 on rat periodontal fibroblasts in-vitro. Australian/New Zealand Division Golden Jubilee Meeting, Sebel Harbourside Hotel, Kiama, New South Wales, Australia,, September 27-29 2010.
Manthey, Helga, Thomas, Anita, Taylor, Stephen, Woodruff, Trent, Moore, Tyson, Shiels, Ian and Rolfe, Barbara (2008). Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September - 2 October 2008. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.molimm.2008.08.167
Clark, Sharon F., Cao, Yang, Croll, Tristan, Jahnke, Sani, Dyne, Al, Rolfe, Barbara, Brooke, Gary, Atkinson, Kerry, Campbell, Julie and Cooper-White, Justin (2007). Surface protein regulators of rat bone marrow-derived mesenchymal stem cell morphology. International Society for Stem Cell Research (ISSCR) Annual Meeting, Cairns, Qld, Australia, 17-20 June, 2007.
Chau, Yu-Qian, Zhang, Bing, Rolfe, Barbara, Wei, Ming and Campbell, Julie (2007). Inhibition of myofibroblast differentiation by silencing transforming growth factor beta receptor. Annual Congress of the European Society of Gene and Cell Therapy, De Doelen, Rotterdam, The Netherlands, 27-30 October, 2007. NEW ROCHELLE: MARY ANN LIEBERT INC.
Manthey, H., Taylor, S., Shiels, I. and Rolfe, B. (2007). Does C5a have a role in the pathophysiology of atherosclerosis?. XXI International Complement Workshop, Beijing, China, 22-26 October 2006. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.molimm.2006.07.154
Campbell, Julie H., Mooney, Jane, Le, Sarah, Walker, Philip, Zhang, Bing, Rolfe, Barbara and Campbell, Gordon R. (2006). The peritoneal cavity as a bioreactor for tissue engineered arteries. XIVth International Vascular Biology Meeting, Noordwijkerhout, Netherlands, 6-10 June 2006. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.vph.2006.08.128
Campbell, J. H., Efendy, J., Chue, W., Daly, C., Mooney, J., Zhang, B., Rolfe, B., Walker, P. and Campbell, G. R. (2005). Artifical arteries from cells of bone marrow origin. Vascular 2005, Sydney, 9-14 Sep, 2005.
Worth, N.F., Rolfe, B.E., Campbell, J.H. and Campbell, G.R. (2004). Rho and smooth muscle cell phenotype. Thirteenth International Symposium on Atherosclerosis, Kyoto, Japan, 27 September - 3 October 2003. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0531-5131(03)01863-6
Worth, N. F., Rolfe, B. E. and Campbell, G. R. (2003). Rho and smooth muscle cell phenotype. 13th International Atherosclerosis Symposium, Kyoto, Japan, 28 September - 2 October 2004. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/S1567-5688(03)90774-4
World, C., Rolfe, B. E. and Campbell, J. H. (2001). Attenuation of smooth muscle proliferation by leukaemia inhibitory factor involves the activation of negative feed-back regulators. COMBIO, Canberra, October 2001.
World, C., Rolfe, B. E. and Campbell, J. H. (2001). The signal attenuating effects of LIF treated vascular smooth muscle cells as a means of inhibiting hyperplasia. Australian Vascular Biology Society 9th Annual Scientific Meeting, Noosa Qld, 30 August - September 2, 2001.
Worth, N.F., Rolfe, B. E. and Campbell, G. R. (2001). Smooth muscle, the cytoskeleton and cell signalling. Australian Vascular Biology Society 9th Scientific Annual Meeting, Noosa, Qld, 30 August - 2 September 2001.
Rolfe, B. E., Worth, N.F. and Campbell, G. R. (2001). Rho as a regulator of smooth muscle phenotype. COMBIO, Canberra, October 2001.
Campbell, G. R., Worth, N. F. and Rolfe, B. E. (2001). A role for Rho in smooth muscle phenotypic regulation. Australian Vascular Biology Society, Noosa, Queensland, Australia, Ausgust, 2001. New York: The Academy.
Worth, N. F., Campbell, G. R. and Rolfe, B. E. (2001). A role for Rho in smooth muscle phenotypic regulation. 6th Saratoga International Conference on Atherosclerosis, Tokyo, Japan, 3-6 April 2001. Malden, MA United States: Wiley-Blackwell. doi: 10.1111/j.1749-6632.2001.tb03955.x
World, C., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (2000). Expression of LIF receptor subunits by cells of the artery wall. The Australian Vascular Biology Society 2000 Annual Scientific Meeting, Marysville, Victoria, 19-22 October 2000. Melbourne: Australian Vascular Biology Society.
Worth, N., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (2000). A role for Rho in smooth muscle phenotypic regulation. International Congress on Differentiation & Cell Biology, Gold Coast, Australia, 24-28 September 2000. Australia: Magic Touch Pty Ltd.
World, C., Rolfe, B. E. and Campbell, J. H. (2000). The role of leukemia inhibitory factor in vascular smooth muscle cell function. International Congress on Differentiation & Cell Biology, Gold Coast, Australia, 24-28 September 2000. Australia: Magic Touch Pty Ltd.
Worth, N., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (2000). Rho and vascular smooth muscle cell phenotype. Xth International Vascular Biology Meeting, Geneva Switzerland, 5-9 September 2000. Siena, Italy: Nova Immagine Editrice - Siena.
Song, J., Rolfe, B. E., Worth, N., Campbell, J. H., Campbell, G. R. and Hayward, I. P. (1999). Modified vascular smooth muscle cell behaviour in vitro by extracellular matrix. The Australian Vascular Biology Society 1999 Annual Scientific Meeting, 321003, 730106. Adelaide: The Aust. Vascular Biology Society 1999 Annual Scientific Meeting.
Worth, N., Rolfe, B. E., Campbell, G. R. and Campbell, J. H. (1999). The influence of the small GTP-binding protein Rho on vascular smooth muscle cell phenotype. Gold Coast, 27-30 Sept, 1999. Kent Town SA: Aust. Society for Biochemistry and Molecular Biology.
Song, J., Rolfe, B. E., Hayward, I. P., Campbell, G. R. and Campbell, J. H. (1999). Behaviour of rabbit aortic smooth muscle cells grown in three-dimensional collagen gel. Combio99 Symposium, Gold Coast, 27-30 Sept 1999. Kent Town SA: Aust. Society for Biochemistry and Molecular Biology ..
Rolfe, BE, Cavanagh, AC, Quinn, KA and Morton, H (1985). Early-Pregnancy Factor - a Suppressor Releasing Hormone. NEW YORK: WILEY-LISS.
Gardiner, RA, Morton, H, Cavanagh, AC and Rolfe, BE (1984). Detection of An Epf-Like Substance in Sera of Patients with Testicular Germ-Cell Tumors. OXFORD: BLACKWELL SCIENCE LTD.
Rolfe, BE, Morton, H, Cavanagh, AC and Gardiner, R (1982). Production of An Epf-Like Substance by Male Germ-Cell Tumors. COPENHAGEN: MUNKSGAARD INT PUBL LTD.
Morton, H, Rolfe, BE and Cavanagh, AC (1982). Early-Pregnancy Factor in Pre-Implantation Pregnancy. COPENHAGEN: MUNKSGAARD INT PUBL LTD.
Thesis
Rolfe, Barbara (1983). Early pregnancy factor : immunological, biochemical and clinical aspects. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/uql.2014.580