Academic Background
BSc, PhD UQ

Research: The Innate Immune System, Cancer Therapeutics and Biomedical Applications of Nanomaterials. 
Dr Barbara Rolfe is an immunologist and cell biologist is an immunologist and cell biologist whose research focuses on myeloid cells and the innate immune response. Her research investigates key questions in biomedical research: 1) biomedical applications of nanomaterials, and how the immune response to nanoparticles influences their in vivo fate, and 2) the application of complement-targeting drugs as cancer therapeutics. 

Researcher biography

A/Prof Barbara Rolfe is a Group Leader at the Australian Institute for Bioengineering and Nanotechnology. A/Prof Rolfe is an immunologist and cell biologist, whose major research interests are the role of the innate immune system in cancer, the identification of novel therapeutic strategies for cancer, and nanomaterial safety. Her research has led to the identification of a previously unknown mechanism by which dysregulation of the immune system contributes to cancer development and growth, and provided information regarding the immune response to nanomaterials and the influence of physicochemical characteristics on biodistribution and cellular uptake. A/Prof Rolfe has used mouse models and small peptide agonists and antagonists to investigate the role of the innate immune system in tumour development and growth. This research demonstrated for the first time an important role for complement proteins in promoting tumour growth via regulation of immunosuppressive innate immune cells. Ongoing research is aimed focussed on gaining a better understanding of the role of complement proteins in tumour growth, developing novel immunotherapeutic strategies for cancer and investigating the application of nanomaterials for targeted delivery of anti-cancer drugs.