Dr Felicity Han
Postdoctoral Research Fellow
School of Biomedical Sciences
+61 7 334 69718
Academic Background
Master of Bioscience, Tropical Agricultural University of South China, China, 1998-2001
PhD in Neuropharmacology and drug delivery, School of Pharmacy, UQ, 2011-2015
Research Interests
1. Nanotechnology in pain management: Novel analgesic drug delivery strategies to alleviate intractable cancer-related pain.
2. Understanding molecular mechanisms of individual chronic pain conditions with particular focus on cancer chemotherapy induced neuropathic pain and osteoarthritis pain for novel pain therapeutics discovery.
Researcher biography
Lecturer(1998-2001), Liaocheng University, China
Senior Editor (2002 – 2007), JIPB, CAS, Beijing, China
Production Technician (2009–2011), Radpharm Scientific, a Division of Global Medical Solutions Australia, Canberra
Casual Tutor (2012-2014) in microbiology, School of Pharmacy, UQ
Research Assistant (2015), CIPDD, Faculty of Medicine, UQ
Postdoctoral Research Fellow (2015- Present), UQCCR, Faculty of Medicine, UQ
Publications
Book Chapter
Han, Felicity Y., McDonald, Tanya, Xu, Weizhi and Borges, Karin (2021). Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments. Clinical bioenergetics: from pathophysiology to clinical translation. (pp. 653-677) edited by Sergej Ostojic. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-819621-2.00029-2
Journal Articles
Liu, Ye, Zhao, Jiufeng, Mu, Xingrui, Deng, Junyu, Wu, Xingqian, He, Wenjie, Liu, Yiqiu, Gu, Rifang, Han, Felicity and Nie, Xuqiang (2024). Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway. Journal of Ethnopharmacology, 319 (Pt 2) 117266, 117266. doi: 10.1016/j.jep.2023.117266
Pang, Huiwen, Wu, Youzhi, Chen, Yang, Chen, Chen, Nie, Xuqiang, Li, Peng, Huang, Guojun, Xu, Zhi Ping and Han, Felicity Y. (2024). Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery. Drug Delivery and Translational Research. doi: 10.1007/s13346-023-01504-7
He, Wenjie, Mu, Xingrui, Wu, Xingqian, Liu, Ye, Deng, Junyu, Liu, Yiqiu, Han, Felicity and Nie, Xuqiang (2024). The cGAS-STING pathway: a therapeutic target in diabetes and its complications. Burns & Trauma, 12 ARTN tkad050. doi: 10.1093/burnst/tkad050
Ye, Penghui, Gu, Rifang, Zhu, Huan, Chen, Jitao, Han, Felicity and Nie, Xuqiang (2023). SOX family transcription factors as therapeutic targets in wound healing: A comprehensive review. International Journal of Biological Macromolecules, 253 (Pt 6) 127243. doi: 10.1016/j.ijbiomac.2023.127243
Nie, Xuqiang, Deng, Youcai, Tong, Xiaoyong and Han, Felicity (2023). Editorial: mechanism and therapeutic potential of macrophages in metabolic and cardiovascular diseases. Frontiers in Immunology, 14 1352567, 1-3. doi: 10.3389/fimmu.2023.1352567
Zhu, Huan, He, Wenjie, Ye, Penghui, Chen, Jitao, Wu, Xingqian, Mu, Xingrui, Wu, Youzhi, Pang, Huiwen, Han, Felicity and Nie, Xuqiang (2023). Piezo1 in skin wound healing and related diseases: mechanotransduction and therapeutic implications. International Immunopharmacology, 123 110779, 110779. doi: 10.1016/j.intimp.2023.110779
Liu, Yiqiu, Lin, Musen, Mu, Xingrui, Qin, Lin, Deng, Junyu, Liu, Ye, Wu, Xingqian, He, Wenjie, Pang, Huiwen, Han, Felicity, Sun, Chengxin and Nie, Xuqiang (2023). Protective effect of solanesol in glucose-induced hepatocyte injury: mechanistic insights on oxidative stress and mitochondrial preservation. Chemico-Biological Interactions, 383 110676, 1-12. doi: 10.1016/j.cbi.2023.110676
Chen, Jitao, Ye, Penghui, Gu, Rifang, Zhu, Huan, He, Wenjie, Mu, Xingrui, Wu, Xingqian, Pang, Huiwen, Han, Felicity and Nie, Xuqiang (2023). Neuropeptide substance P: a promising regulator of wound healing in diabetic foot ulcers. Biochemical Pharmacology, 215 115736, 115736. doi: 10.1016/j.bcp.2023.115736
Ediriweera, Gayathri R., Chang, Yixin, Wang, Qiaoyun, Gong, Yutong, Akhter, Dewan T., Pang, Huiwen, Han, Felicity Y., Chen, Chunying, Whittaker, Andrew K. and Fu, Changkui (2023). Stimuli-responsive sulfoxide polymer–protein conjugates with improved pharmacokinetics and tumor delivery. Chemistry of Materials, 35 (17), 7252-7265. doi: 10.1021/acs.chemmater.3c01566
Pang, Huiwen, Chen, Shihui, Klyne, David M., Harrich, David, Ding, Wenyuan, Yang, Sidong and Han, Felicity Y. (2023). Low back pain and osteoarthritis pain: a perspective of estrogen. Bone Research, 11 (1) 42, 42. doi: 10.1038/s41413-023-00280-x
Zhao, Ruoyu, Huo, Yachong, Yeo, Trifanny, Han, Felicity Y., Ma, Lei, Yang, Dalong, Ding, Wenyuan and Yang, Sidong (2023). Application of stand-alone oblique lateral interbody fusion in L4-5 lumbar diseases. Journal of Visualized Experiments, 2023 (195) e65351, 1-12. doi: 10.3791/65351
Pang, Huiwen, Huang, Xiangquan, Xu, Zhi Ping, Chen, Chen and Han, Felicity Y. (2023). Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes. Drug Discovery Today, 28 (1) 103393, 1-11. doi: 10.1016/j.drudis.2022.103393
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030
Tian, Xiaoming, Huo, Yachong, Han, Felicity Y., Yang, Dalong, Ding, Wenyuan and Yang, Sidong (2022). Modified posterior vertebral column resection for patients with thoracolumbar kyphotic deformity. Journal of Visualized Experiments, 2022 (187) e64465, 1-10. doi: 10.3791/64465
Tian, Xiaoming, Zhao, Hongwei, Han, Felicity Y., Rudd, Samuel, Li, Zhaohui, Ding, Wenyuan and Yang, Sidong (2022). Treatment of three-level cervical spondylotic myelopathy using ACDF or a combination of ACDF and ACCF. Frontiers in Surgery, 9 1021643, 1021643. doi: 10.3389/fsurg.2022.1021643
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109
Zhao, Ruoyu, Ding, Wenyuan, Li, Xiangyu, Han, Felicity Y., Yang, Dalong and Yang, Sidong (2022). Application of the O-arm Intraoperative Imaging System to Assist Anterior Cervical Screw Fixation for Odontoid Fractures. Journal of Visualized Experiments, 2022 (186) e64471. doi: 10.3791/64471
Chang, Yixin, Wang, Qiaoyun, Xu, Weizhi, Huang, Xumin, Xu, Xin, Han, Felicity Y., Qiao, Ruirui, Ediriweera, Gayathri R., Peng, Hui, Fu, Changkui, Liu, Kun and Whittaker, Andrew K. (2022). Low-fouling gold nanorod theranostic agents enabled by a sulfoxide polymer coating. Biomacromolecules, 23 (9), 3866-3874. doi: 10.1021/acs.biomac.2c00696
Young Seo, Gi, Neal, Elliott S., Han, Felicity, Vidovic, Diana, Nooru‐Mohamed, Fathima, Dienel, Gerald A., Sullivan, Mitchell A. and Borges, Karin (2022). Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy. Epilepsia Open, 7 (2), 361-367. doi: 10.1002/epi4.12599
Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree Therese (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology, 33 (1), 23-31. doi: 10.1097/fbp.0000000000000663
Zhu, Minze, Whittaker, Andrew K., Han, Felicity Y. and Smith, Maree T. (2022). Journey to the market: The evolution of biodegradable drug delivery systems. Applied Sciences, 12 (2) 935. doi: 10.3390/app12020935
Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3
Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint. Clinical and Experimental Pharmacology and Physiology, 48 (11) 1440-1681.13551, 1515-1522. doi: 10.1111/1440-1681.13551
Han, Felicity Y., Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria, Jiang, Xingyu, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2021). Optimisation of a microfluidic method for the delivery of a small peptide. Pharmaceutics, 13 (9) 1505, 1505. doi: 10.3390/pharmaceutics13091505
Han, Felicity Y., Conboy‐Schmidt, Lisa, Rybachuk, Galena, Volk, Holger A., Zanghi, Brian, Pan, Yuanlong and Borges, Karin (2021). Dietary medium chain triglycerides for management of epilepsy: new data from human, dog, and rodent studies. Epilepsia, 62 (8) epi.16972, 1790-1806. doi: 10.1111/epi.16972
Li, Li, Qian, Yujin, Sun, Luyao, Han, Felicity Y., Zhang, Run, Wang, Peng-Yuan and Xu, Zhi Ping (2021). Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment. Nanomedicine: Nanotechnology, Biology, and Medicine, 34 102369, 102369. doi: 10.1016/j.nano.2021.102369
Raza, Aun, Alavi, Seyed Ebrahim, Sime, Fekade Bruck, Han, Felicity Y., Roberts, Jason A., Popat, Amirali, Falconer, James R. and Kumeria, Tushar (2021). Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery. Acta Biomaterialia, 126, 277-290. doi: 10.1016/j.actbio.2021.03.042
Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w
Garms, Bruna C., Poli, Hamish, Baggley, Darcy, Han, Felicity Y., Whittaker, Andrew K., A, Anitha and Grøndahl, Lisbeth (2021). Evaluating the effect of synthesis, isolation, and characterisation variables on reported particle size and dispersity of drug loaded PLGA nanoparticles. Materials Advances, 2 (17), 5657-5671. doi: 10.1039/d1ma00410g
Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T. and Han, Felicity Y. (2020). Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain. Pharmaceutical Research, 37 (10) 211, 1-12. doi: 10.1007/s11095-020-02939-0
Zhang, Cheng, Moonshi, Shehzahdi Shebbrin, Wang, Wenqian, Ta, Hang Thu, Han, Yanxiao, Han, Felicity Y., Peng, Hui, Král, Petr, Rolfe, Barbara E., Gooding, J. Justin, Gaus, Katharina and Whittaker, Andrew K. (2020). Correction to High F-content perfluoropolyether-based nanoparticles for targeted detection of breast cancer by 19F magnetic resonance and optical imaging. ACS Nano, 14 (10), 14245-14246. doi: 10.1021/acsnano.0c07373
Cao, Pei, Han, Felicity Y., Grøndahl, Lisbeth, Xu, Zhi Ping and Li, Li (2020). Enhanced oral vaccine efficacy of polysaccharide-coated calcium phosphate nanoparticles. ACS Omega, 5 (29), 18185-18197. doi: 10.1021/acsomega.0c01792
Yu, Ye, Xu, Weizhi, Huang, Xumin, Xu, Xin, Qiao, Ruirui, Li, Yuhuan, Han, Felicity, Peng, Hui, Davis, Thomas P., Fu, Changkui and Whittaker, Andrew K. (2020). Proteins conjugated with sulfoxide-containing polymers show reduced macrophage cellular uptake and improved pharmacokinetics. ACS Macro Letters, 9 (6), 799-805. doi: 10.1021/acsmacrolett.0c00291
Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah, Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent, Kent, Stephen, Searles, Debra and Whittaker, Andrew (2020). Low-fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie International Edition, 59 (12), 4729-4735. doi: 10.1002/anie.201914119
Fu, Changkui, Demir, Baris, Alcantara, Sheilajen, Kumar, Vinod, Han, Felicity, Kelly, Hannah G., Tan, Xiao, Yu, Ye, Xu, Weizhi, Zhao, Jiacheng, Zhang, Cheng, Peng, Hui, Boyer, Cyrille, Woodruff, Trent M., Kent, Stephen J., Searles, Debra J. and Whittaker, Andrew K. (2020). Low‐fouling fluoropolymers for bioconjugation and in vivo tracking. Angewandte Chemie, 132 (12), 4759-4765. doi: 10.1002/ange.201914119
Zhang, Cheng, Li, Li, Han, Felicity Y., Yu, Xinying, Tan, Xiao, Fu, Changkui, Xu, Zhi Ping and Whittaker, Andrew K. (2019). Integrating fluorinated polymer and manganese‐layered double hydroxide nanoparticles as pH‐activated 19 F MRI agents for specific and sensitive detection of breast cancer. Small, 15 (36) 1902309, 1902309. doi: 10.1002/smll.201902309
Fu, Changkui, Tang, Joyce, Pye, Aidan, Liu, Tianqing, Zhang, Cheng, Tan, Xiao, Han, Felicity, Peng, Hui and Whittaker, Andrew K. (2019). Fluorinated glycopolymers as reduction-responsive 19F MRI agents for targeted imaging of cancer. Biomacromolecules, 20 (5) acs.biomac.9b00241, 2043-2050. doi: 10.1021/acs.biomac.9b00241
Zhu, Minze, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2019). Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology. Journal of Pharmaceutical Sciences, 108 (3), 1220-1226. doi: 10.1016/j.xphs.2018.10.029
Han, Felicity Y., Whittaker, Andrew, Howdle, Steven M., Naylor, Andrew, Shabir-Ahmed, Anjumn and Smith, Maree T. (2019). Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation. Journal of Pharmaceutical Sciences, 108 (2), 811-814. doi: 10.1016/j.xphs.2018.09.021
Han, Felicity, Whittaker, Andrew, Howdle, Steven, Naylor, Andrew, Shabir-Ahmed, Anjumn, Zhang, Cheng and Smith, Maree (2018). Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics, 10 (4) 264, 264. doi: 10.3390/pharmaceutics10040264
Han, Felicity Y., Kuo, Andy, Nicholson, Janet R., Corradinni, Laura and Smith, Maree T. (2018). Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy. Clinical and Experimental Pharmacology and Physiology, 45 (10), 1067-1075. doi: 10.1111/1440-1681.12971
Zhang, Cheng, Moonshi, Shehzahdi Shebbrin, Wang, Wenqian, Ta, Hang Thu, Han, Yanxiao, Han, Felicity Y., Peng, Hui, Král, Petr, Rolfe, Barbara E., Gooding, John Justin, Gaus, Katharina and Whittaker, Andrew Keith (2018). High F-content perfluoropolyether-based nanoparticles for targeted detection of breast cancer by 19F magnetic resonance and optical imaging. ACS Nano, 12 (9) acsnano.8b03726, 9162-9176. doi: 10.1021/acsnano.8b03726
Fu, Changkui, Zhang, Cheng, Peng, Hui, Han, Felicity, Baker, Carly, Wu, Yuao, Ta, Hang and Whittaker, Andrew K. (2018). Enhanced performance of polymeric 19F MRI contrast agents through incorporation of highly water-soluble monomer MSEA. Macromolecules, 51 (15) acs.macromol.8b01190, 5875-5882. doi: 10.1021/acs.macromol.8b01190
Han, Felicity Y., Thurecht, Kristofer J., Whittaker, Andrew K. and Smith, Maree T. (2016). Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading. Frontiers in Pharmacology, 7 (JUN) 185, 1-11. doi: 10.3389/fphar.2016.00185
Han, Felicity Y., Thurecht, Kristofer J., Lam, Ai-Leen, Whittaker, Andrew K. and Smith, Maree T. (2015). Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. Journal of Pharmaceutical Sciences, 104 (7), 2334-2344. doi: 10.1002/jps.24497
Jia, Husen, Dwyer, Simon A., Fan, Da-Yong, Han, Yaqin, Badger, Murray R., von Caemmerer, Susanne and Chow, Wah Soon (2014). A novel P700 redox kinetics probe for rapid, non-intrusive and whole-tissue determination of photosystem II functionality, and the stoichiometry of the two photosystems in vivo. Physiologia Plantarum, 152 (3), 403-413. doi: 10.1111/ppl.12235
Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014). Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 (8), 732-740. doi: 10.1097/FBP.0000000000000090
Han, Yaqin and Smith, Maree T. (2013). Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4 Article 156, 1-16. doi: 10.3389/fphar.2013.00156
Han, Ya-Qin, Yan, Xing-Fu, Zhang, Hua, Hu, Zheng-Hai, Hao, Bing-Zhong and Tian, Wei-Min (2007). Fluctuation of vegetative storage proteins in the seedlings of Swietenia macrophylla, analogous to the seasonal changes of those in the shoot of the adult tree. Journal of Integrative Plant Biology, 49 (3), 362-367. doi: 10.1111/j.1672-9072.2007.00437.x
Tian, Weimin, Han, Yaqin, Wu, Ji-Lin and Hu, Zheng-Hai (2003). Fluctuation of microfibrillar protein level in lutoids of primary laticifers in relation to the 67kDa storage protein in Hevea brasiliensis. Acta Botanica Sinica, 45 (2), 127-130.
Jia, Husen, Han, Yaqin and Li, Dequan (2003). Photoinhibition and active oxygen species production in detached apple leaves during dehydration. Photosynthetica, 41 (1), 151-155. doi: 10.1023/A:1025889219115
Tian, WM, Han, YQ, Wu, JL and Hao, BZ (1998). Characteristics of protein-storing cells associated with a 67 kDa protein in Hevea brasiliensis. Trees-Structure and Function, 12 (3), 153-159. doi: 10.1007/PL00009705
Conference Paper
Zhang, Cheng, Moonshi, Shehzahdi Shebbrin, Ta, Hang T., Han, Yanxiao, Han, Felicity Y., Peng, Hui, Král, Petr, Rolfe, Barbara E. and Whittaker, Andrew K. (2018). High F-Content Perfluoropolyether-based Polymers for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging. World Polymer Congress Macro 2018, Cairns QLD Australia, 1-5 July 2018.
Data Collection
Han, Felicity, Kumeria, Tushar and Falconer, James R. (2019). HaBS-Med Collaborative Seeding Grants 2019. The University of Queensland. (Dataset) doi: 10.14264/uql.2019.756
Thesis
Han, Felicity Yaqin (2015). Cancer chemotherapy induced peripheral neuropathy (CIPN): preclinical studies. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/uql.2015.831