Dr Helga Manthey
Research Fellow
Australian Institute for Bioengineering and Nanotechnology
+61 7 33463856
Journal Articles
Akhir, Fazrena Nadia Md, Noor, Mohd Hezmee Mohd, Leong, Keith Weng Kit, Nabizadeh, Jamileh A., Manthey, Helga D., Sonderegger, Stefan E., Fung, Jenny Nga Ting, McGirr, Crystal E., Shiels, Ian A., Mills, Paul C., Woodruff, Trent M. and Rolfe, Barbara E. (2021). An immunoregulatory role for complement receptors in murine models of breast cancer. Antibodies, 10 (1) 2, 1-12. doi: 10.3390/antib10010002
Rolfe, Barbara E., Pio, Ruben, Woodruff, Trent M., Markiewski, Maciej M. and Manthey, Helga D. (2020). Editorial: The Role of Complement in Tumors. Frontiers in Immunology, 11 139, 139. doi: 10.3389/fimmu.2020.00139
Nabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., Akhir, Fazrena N. M., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. FASEB Journal, 33 (10), fj201800980RR-11071. doi: 10.1096/fj.201800980rr
Vorlova, Sandra, Koch, Miriam, Manthey, Helga D., Cochain, Clement, Busch, Martin, Chaudhari, Sweena M., Stegner, David, Yepes, Manuel, Lorenz, Kristina, Nolte, Marc W., Nieswandt, Bernhard and Zernecke, Alma (2017). Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice. Thrombosis and Haemostasis, 117 (1), 176-187. doi: 10.1160/TH16-06-0466
Nabizadeh, Jamileh A., Manthey, Helga D., Steyn, Frederik J., Chen, Weiyu, Widiapradja, Alexander, Akhir, Fazrena N. Md, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2016). The complement C3a receptor contributes to melanoma tumorigenesis by inhibiting neutrophil and CD4+ T cell responses. Journal of Immunology, 196 (11), 4783-4792. doi: 10.4049/jimmunol.1600210
Chaudhari, Sweena M., Sluimer, Judith C., Koch, Miriam, Theelen, Thomas L., Manthey, Helga D., Busch, Martin, Caballero-Franco, Celia, Vogel, Frederick, Cochain, Clement, Pelisek, Jaroslav, Daemen, Mat J., Lutz, Manfred B., Görlach, Agnes, Kissler, Stephan, Hermanns, Heike M. and Zernecke, Alma (2015). Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (11), 2316-2325. doi: 10.1161/ATVBAHA.115.306171
Manthey, H. D., Cochain, C., Barnsteiner, S., Karshovska, E., Pelisek, J., Koch, M., Chaudhari, S. M., Busch, M., Eckstein, H. H., Weber, C., Koenen, R. R. and Zernecke, A. (2013). CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Thrombosis and Haemostasis, 110 (6), 1267-1277. doi: 10.1160/TH13-01-0017
Matsumoto, Aya, Manthey, Helga D., Marsh, Susan A., Fassett, Robert G., de Haan, Judy B., Rolfe, Barbara E. and Coombes, Jeff S. (2013). Effects of exercise training and RhoA/ROCK inhibition on plaque in ApoE−/− mice. International Journal of Cardiology, 167 (4), 1282-1288. doi: 10.1016/j.ijcard.2012.03.172
Michalska, Marta, Machtoub, Lina, Manthey, Helga D., Bauer, Elisabeth, Herold, Volker, Krohne, Georg, Lykowsky, Gunthard, Hildenbrand, Markus, Kampf, Thomas, Jakob, Peter, Zernecke, Alma and Bauer, Wolfgang R. (2012). Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule-1-specific nanoparticles. Arteriosclerosis Thrombosis and Vascular Biology, 32 (10), 2350-2357. doi: 10.1161/ATVBAHA.112.255224
Doering, Yvonne, Manthey, Helga D., Drechsler, Maik, Lievens, Dirk, Megens, Remco T. A., Soehnlein, Oliver, Busch, Martin, Manca, Marco, Koenen, Rory R., Pelisek, Jaroslav, Daemen, Mat J., Lutgens, Esther, Zenke, Martin, Binder, Christoph J., Weber, Christian and Zernecke, Alma (2012). Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation, 125 (13), 1673-1683. doi: 10.1161/CIRCULATIONAHA.111.046755
Manthey, Helga D. and Zernecke, Alma (2011). Dendritic cells in atherosclerosis: functions in immune regulation and beyond. Thrombosis and Haemostasis, 106 (5), 772-778. doi: 10.1160/TH11-05-0296
Manthey, Helga D., Thomas, Anita C., Shiels, Ian A., Zernecke, Alma, Woodruff, Trent M., Rolfe, Barbara and Taylor, Stephen M. (2011). Complement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice. FASEB Journal, 25 (7), 2447-2455. doi: 10.1096/fj.10-174284
Manthey, Helga D., Woodruff, Trent M., Taylor, Stephen M. and Monk, Peter N. (2009). Complement component 5a (C5a). International Journal of Biochemistry and Cell Biology, 41 (11), 2114-2117. doi: 10.1016/j.biocel.2009.04.005
Woodruff, T. M., Pollitt, S., Proctor, L. M., Stocks, S. Z., Manthey, H. D., Williams, H. M., Mahadevan, I. B., Shiels, I. A. and Taylor, S. M. (2005). Increased potency of a novel complement factor 5a receptor antagonist in a rat model of inflammatory bowel disease. Journal of Pharmacology And Experimental Therapeutics, 314 (2), 811-817. doi: 10.1124/jpet.105.086835
Conference Papers
Wu, M. C. L., Moore, T. A., Manthey, H. D., Taylor, S. M. and Woodruff, T. M. (2010). The role of complement anaphylatoxin receptors in mesenteric ischemia/reperfusion-induced injury. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K.: Pergamon Press. doi: 10.1016/j.molimm.2010.05.216
Manthey, Helga, Thomas, Anita, Taylor, Stephen, Woodruff, Trent, Moore, Tyson, Shiels, Ian and Rolfe, Barbara (2008). Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September - 2 October 2008. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.molimm.2008.08.167
Moore, Tyson, Woodruff, Trent, Manthey, Helga, Monk, Peter, Taylor, Stephen and Shiels, Ian (2008). Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September-2 October 2008. Oxford, United Kingdom: Elseiver. doi: 10.1016/j.molimm.2008.08.165
Denny, Kerina, Woodruff, Trent, Pavlovski, Dale, Manthey, Helga, Paul Colditz, Richard Finnell and Stephen Taylor (2008). The role of C5a in reproductive impairment in the mouse and human. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September - 2 October 2008. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.molimm.2008.08.164
Manthey, H., Taylor, S., Shiels, I. and Rolfe, B. (2007). Does C5a have a role in the pathophysiology of atherosclerosis?. XXI International Complement Workshop, Beijing, China, 22-26 October 2006. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.molimm.2006.07.154
Thesis
Helga Manthey (2010). Defining the role of C5a in atherosclerosis. PhD Thesis, School of Biomedical Sciences, The University of Queensland.